Panama Canal cruises

Panama Canal One-Way: Cabo San Lucas, Ketchikan & Panama Canal

Cabo San Lucas · Puerto Vallarta · Ketchikan · Panama Canal · Cartagena

Balanced itinerary with more sea time than port-packed variants. Covers Mexico, United States, Panama, and Colombia. Includes scenic-cruising segments.

14 nights San Diego Panama Canal 5 ports 8 sea days

What this trip feels like

Easygoing, familiar and ship-focused

8 sea days give you plenty of uninterrupted time onboard, while Cabo San Lucas, Puerto Vallarta, and Ketchikan provide the trip's main day ashore. You're choosing this route for an easy break with minimal logistics, not destination variety.

Relaxed pace

5 ports in 14 nights

Plenty of uninterrupted ship time.

Broad destination variety

Cabo San Lucas · Puerto Vallarta · Ketchikan + more

Frequent changes of scenery across the itinerary.

Route logistics

Sails from San Diego

Check the exact departure and arrival ports before arranging flights.

Port experience

Cabo San Lucas · Plan around the tender

Getting ashore usually requires tendering, and cruise traffic can add pressure to your port day.

Best for · First-time cruisers · Ship-focused trips · Easy short getaways

Think twice if · You want a port-intensive Panama Canal itinerary

Best departures

Best upcoming sailings

Start here. These departures surface first because they combine stronger pricing, useful timing, or a notable warning signal for this itinerary.

All departures

All upcoming departures

Compare all sailings for this itinerary.

Itinerary pricing

What this itinerary usually costs

Typical pricing runs around $250/night, with most departures landing in the $204-$336/night band across 1 tracked sailing.

Typical price

$250/night

$3,497 total

Normal range

$204-$336/night

$2,859-$4,707 total

Lowest recent fare

$186/night

$2,606 total

Comparison set

1 sailings

Used for itinerary baseline

When should I go?

Not enough departures yet to identify a reliable cheaper season.

Route overview

How this route is built

Compare sailings →

14 nights · 5 port calls · 8 sea days · 4 countries

5 port calls across Mexico, United States, Panama, Colombia · Leans more toward sea time than a port-packed 14-night route.

  1. 1

    Embark in San Diego

    Embarkation ports can vary by sailing

  2. 2

    Cabo San Lucas

    Mexico · Mexican Riviera

  3. 3

    Puerto Vallarta

    Mexico · Mexican Riviera

  4. 4

    Ketchikan

    United States · Alaska Inside Passage

  5. 5

    Panama Canal

    Panama · Panama Canal

    Scenic cruising
  6. 6

    Cartagena

    Colombia · Southern Caribbean

  7. 7

    Disembark in Galveston

    Disembarkation ports can vary by sailing

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Embark port
Disembark port
Port of call

Other routes to consider

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