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Panama Canal cruises

Panama Canal One-Way via San Diego, Cabo San Lucas & Panama Canal

San Diego · Cabo San Lucas · Puntarenas · Panama Canal · Colón (Panama Canal) · Cartagena

Balanced route with a steady mix of port days and sea days. Covers United States, Mexico, Costa Rica, Panama, and more. Includes scenic-cruising segments.

15 nights Los Angeles Panama Canal 7 ports 8 sea days
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What this trip feels like

Balanced, varied and easy to pace

This route gives you a steady mix of ship time and 7 ports. It suits travelers who want meaningful days ashore without turning every day into an early start and a tightly planned port call.

Balanced pace

7 ports in 15 nights

A steady alternation between time onboard and time ashore.

Broad destination variety

San Diego · Cabo San Lucas · Puntarenas + more

Frequent changes of scenery across the itinerary.

Route logistics

Sails from Los Angeles

Check the exact departure and arrival ports before arranging flights.

Port experience

San Diego · Pick your date carefully

Cruise traffic varies substantially by date, so your specific port day can feel very different depending on when you visit.

Best for · A mix of ship and shore time · First-time visitors · Travelers who like a steady pace

Think twice if · You want either an all-ports itinerary or a mostly ship-focused escape

Best departures

Best upcoming sailings

Start here. These departures surface first because they combine stronger pricing, useful timing, or a notable warning signal for this itinerary.

Best overall value
MSC Cruises

MSC Poesia

Los Angeles → San Diego → Cartagena → Miami

Oct 2 · 15 nights

$1,830 balcony · $122/night

Limited price history

All departures

All upcoming departures

Compare all sailings for this itinerary.

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Itinerary pricing

What this itinerary usually costs

Typical pricing runs around $131/night, with most departures landing in the $72-$190/night band across 1 tracked sailing.

Typical price

$131/night

$1,964 total

Normal range

$72-$190/night

$1,081-$2,846 total

Lowest recent fare

$122/night

$1,830 total

Comparison set

1 sailings

Used for itinerary baseline

When should I go?

Not enough departures yet to identify a reliable cheaper season.

Route overview

How this route is built

Compare sailings →

15 nights · 7 port calls · 8 sea days · 5 countries

7 port calls across United States, Mexico, Costa Rica, Panama · Neither especially port-heavy nor sea-day heavy for this trip length.

  1. 1

    Embark in Los Angeles

    Embarkation ports can vary by sailing

  2. 2

    San Diego

    United States · West Coast

  3. 3

    Cabo San Lucas

    Mexico · Mexican Riviera

  4. 4

    Puntarenas

    Costa Rica · Central America

  5. 5

    Panama Canal

    Panama · Panama Canal

    Scenic cruising
  6. 6

    Panama Canal

    Panama · Panama Canal

    Scenic cruising
  7. 7

    Colón (Panama Canal)

    Panama · Panama Canal

  8. 8

    Cartagena

    Colombia · Southern Caribbean

  9. 9

    Disembark in Miami

    Disembarkation ports can vary by sailing

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Embark port
Disembark port
Port of call

Other routes to consider

Not quite the right itinerary? Compare routes that trade a little simplicity for more ports, different destinations, or a longer trip.

FAQ

What’s the best month to sail this itinerary?
It depends on weather and crowd levels. Use the sailing list to compare dates and prioritize port days with comfortable conditions.
Are these sailings all the same route?
They can be close but not identical. Look for differences in port order, arrival times, and sea day placement.
How should I choose between two similar sailings?
Compare: (1) ship, (2) port day timing, (3) number of sea days, (4) price vs cabin value, and (5) flight convenience.